ABSTRACT
The clinical spectrum of COVID-19 is extremely variable. Thus, it is likely that the heterogeneity in the genetic make-up of the host may contribute to disease severity. Toll-like receptor (TLR)8 plays a vital role in the innate immune response to SARS-CoV-2 infection. We genotyped 60 adult COVID-19 samples taken from 20 patients, 20 recovery persons and 20 healthy people for TLR8 (rs3764880 A/G) polymorphisms usingTetra-ARMS Technique. The frequency of alleles of TLR8 gene polymorphism of A allele is 57.5% in patients and 60.0% in control group, while frequency of G allele is 42.5% in patients and 40.0% in control group. While, the frequency of alleles of TLR8 gene polymorphism of A allele is 55.0% in recovery and 60.0% in control group, while frequency of G allele is 45.0% in recovery and 40.0% in control group.
ABSTRACT
Infection by the Covid-19 produces in people an illness of profoundly factor and erratic seriousness. The presence of continuous hereditary single nucleotide polymorphisms (SNPs) in the population could prompt a more prominent weakness to infections or an overstated provocative reaction. We concentrated on the relationship between SNP from AGTR1 gene and the seriousness of the infection created by the SARS-Cov-2 infection. Methods: 30 (18 of male and 12 of Female) Covid-19 patients with age range from 55-60 years were assembled in light of the seriousness of side effects. Results: one SNP rs5186 in AGTR1 gene were related with the seriousness of illness. Our results were showed that the rs5186 (C) allele in AGTR1 gene is associated with increased risk for Covid 19 based on OR value: homozygous allele CC has 2.5(0.7-8.5), allele C with allele frequency 20 more than control group, and with OR=2.5(1.5-5.9) with significant P values (P=0.03).